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Center for Advanced Drug Research

Welcome to the Centre of Advanced Drug Research (CADR) at COMSATS University. Through our website you can insight the innovative and collaborative work at CADR.


Message from Head of CADR

PROFESSOR DR. JAMSHED IQBAL
         (Tamgha–i-Imtiaz)
Head, Centre for Advanced Drug Research (CADR) Department of Pharmacy
COMSATS Institute of Information Technology, Abbottabad
Tel: + 92-336-5101651; +92-992-383591-96
Fax: + 92-992-383441
Email: drjamshed@ciit.net.pk; jamshediqb@googlemail.com
http://ciit-atd.edu.pk/cadr

Welcome to the Centre of Advanced Drug Research (CADR) at COMSATS University. Through our website you can insight the innovative and collaborative work at CADR. At CADR we study the crucially important topics in science. They advance it, rather than just learning about it.The type of research being done defines the institution status so it plays a key role in the development of the institution. Our research group has contributed a lot in this regard. I am devoted to strengthen the splendid work contributed to the foundation of our research group.
In order to prepare our students to tackle different sought of problems intheir research work we give them a strong qualitative and quantitative background which is the basis for their success to obtain good results. Read More










Area of Interest

Medicinal chemistry, Enzyme kinetics, Natural products chemistry, Drug discovery and metabolism, Molecular modeling, Molecular toxicology

Personal

Date of Birth

April 15, 1973 (Sialkot, Pakistan)

Languages

English, German, Urdu, Punjabi

N.I.C. No.

276374-100795-1


Education

2010

Post doc., Dalian Institute of Chemical Physics Chinese Academy of Sciences, Dalian, China “Microfluidic-based drug screening at molecular level- Enzymatic reaction in pico liter using microdroplets”

2009

Post doc., Pharmaceutical Institute, University of Bonn, Germany “Development and automatization of capillary electrophoresis-based enzyme assays at nano-scale level for the characterization and screening of NTPDase inhibitors”

2005

Ph.D., Pharmaceutical Institute, University of Bonn, Germany Dissertation supervisor: Prof. Dr. Christa E. Müller “Development of capillary electrophoresis-based nucleoside and nucleotide metabolizing enzyme assays”

2001

M.Sc., Pharmaceutical Analysis, University of Strathclyde, Glasgow, UK Thesis supervisor: Prof. Dr. Gavin W. Halbert “Identification of RH1 (aziridinyl benzoquinone) degradation products”

1999

M.Phil., Analytical/Inorganic Chemistry, Quaid-I-Azam University, Islamabad, Pakistan.
Thesis supervisor: Prof. Dr. M. Ikram “Determination of lead in road side soil, gasoline by AAS and UV-Vis spectrophotometer and development of micro emulsion method for the determination of lead in gasoline”

1996

M.Sc., in Chemistry, Bahauddin Zakriya University, Multan, Pakistan
Thesis supervisor: Prof. Dr. M.Younis Khokhar “Determination of trace metals in sweets by AAS using micro column flow Injection Analysis”

1993

B.Sc., Govt. Degree College Okara, Punjab University Lahore, Pakistan (Chemistry, Zoology and Botany)

1991

F.Sc., Jinnah Islamia College, Sialkot, Pakistan (Chemistry, Biology and Physics)

1988

SSc., (Chemistry, Biology, Physics and Mathematics)


Professional Experience
2013 – Present Head, Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad, Pakistan
Professor, Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan

2007- 2013

Associate Professor, Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan

2009-2010

CAS International young researcher, Dalian Institute of Chemical Physics Chinese Academy of Sciences, Dalian, China

2005-2009

Senior Research Associate, Pharmaceutical Institute, University of Bonn, Germany

2001- 2005

Research Associate, Pharmaceutical Institute, University of Bonn, Germany

1999- 2007

Lecturer, Department of Pharmacy, Islamia University, Bahawalpur, Pakistan

1997- 1999

Research Associate, Central Laboratory for Environmental Analysis (CLEAN), Pakistan Environmental Protection Agency, Islamabad, Pakistan


Awards and Scholarship

1. Tamgha-i-Imtiaz, 2012, Pakistan's highest civilian decorations awarded by president of Pakistan.

2. Research Productivity Award for 2011, 2012, 2013, 2014 & 2015 by COMSATS Institute of Information Technology.

3. Research Productivity Award for 2013, 2014 & 2015 by Pakistan Council for Science and Technology (PCST), Islamabad. In 2015, the award was in the highest category “A”.

4. Most Cited Paper 2006-2009 Award from Elsevier Publishers, Christa E. Müller, Jamshed Iqbal, Younis Baqi, Herbert Zimmermann, Anita Röllich, Holger Stephan. “Polyoxometalates - a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors.Bioorganic & Medicinal Chemistry Letters (2006) 16 (23), 5943-5947

5. Pakistan 50th Anniversary Fund Scholarship for M.Sc. at University of Strathclyde, Glasgow, UK.

6. DAAD, STIBET Scholarship for Postdoc at University of Bonn, Germany.

7. CAS Research Fellowship for International Young Researchers. Research Fellow (2009- 2010): Dalian Institute of Chemical Physics, CAS, 457 Zhongshan Road, 116023, Dalian, Chinese Academy of Sciences.

8. International Young Researchers award given by President of Chinese Academy of Sciences, China.

9. Merit Scholarship (University Grants Commission of Pakistan) for M.Phil. studies at Quaid-i-Azam University, Islamabad.

10. Travel grant from GlaxoSmithKline for participation in 8th International Symposium on Adenosine and Adenine Nucleotides. University of Ferrara, Italy, May 24 - 28, 2006.

11. Travel grant from GlaxoSmithKline for Second Joint Italian-German Purine Club Meeting Leipzig, Germany, September 12-15, 2007.

12. Travel grant from GlaxoSmithKline for Microscale bio-separations and methods for systems biolog, Berlin, Germany, March 9-13, 2008 (MSB 2008).

13. Travel grant from GlaxoSmithKline for Purines 2008 Meeting 29th June – 2nd July 2008, Copenhagen, Denmark.

Membership of scientific associations

1. Member of Royal Pharmaceutical Society of Great Britain (RPSGB)

2. Member of German Pharmaceutical Society (DPhG)

Editorial member

1- Lead Guest Editor: BioMed Research International (Impact Factor 2.880) Thematic Issue “Recent Developments of Carbonic Anhydrase Inhibitors as Potential Drugs”.here

2- Guest Editor: Mini-Reviews in Medicinal Chemistry (Impact Factor 2.865)

Thematic Issue “Ectonucleotidases as Novel Drug Targets: Recent Advances in Therapeutic Applications”.

Research publications (Total Impact Factor = 320)

2016

1. Imtiaz Khan, Sumera Zaib, Sadaf Batool, Naeem Abbas, Zaman Ashraf, Jamshed Iqbal,

Aamer Saeed. Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological diversification. Bioorganic and Medicinal Chemistry (2016) 24: 2361– 2381. IF=2.793

2. Mariya al-Rashida, Gazala Batool, Almas Sattar, Syeda Abida Ejaz, Samiullah Khan, Joanna Lecka, Jean Sévigny, Abdul Hameed, Jamshed Iqbal. 2-Alkoxy-3- (sulfonylarylaminomethylene)-chroman-4-ones as potent and selective inhibitors of ectonucleotidases. European Journal of Medicinal Chemistry (2016) 115: 484–494

IF=3.447

3. Aamer Saeed, Syeda Abida Ejaz, Muddasar Shehzad, Sidra Hassan, Mariya al-Rashida, Joanna Lecka, Jean Sévigny, Jamshed Iqbal. 3-(5-(Benzylideneamino)thiozol-3-yl)-2H- chromen-2-ones: A new class of alkaline phosphatase and ecto-5′-nucleotidase inhibitors.

RSC Advances (2016) 6: 21026-21036. IF=3.84

4. Jamshed Iqbal, Aamer Saeed, Syed Jawad Ali Shah, Mariya al-Rashida, Shams-ul Mahmood. Biological evaluation of azomethine-dihydroquinazolinone conjugates as cancer and cholinesterase inhibitors. Medicinal Chemistry. (2016) 12(1): 74-82. IF=1.363

5. Anton Ivanov, Sebastian Boldt, Zaib un Nisa, Syed Jawad Ali Shah, Peter Ehlers, Alexander Villinger, Gyula Schneider, János Wölfling, Qamar Rahman, Jamshed Iqbal, Peter Langer. Synthesis, Functionalisation and Phosphatase Inhibitory Activity of 3- Alkynylestrones. RSC Advances (2016) 6: 11118-11127. IF=3.84

6. Mariia Miliutina, Syeda Abida Ejaz, Viktor O. Iaroshenko, Alexander Villinger,

Jamshed Iqbal, Peter Langer. Synthesis of 3,3‘-Carbonyl-bis(chromones) and their Activity as Mammalian Alkaline Phosphatase Inhibitors. Organic & Biomolecular Chemistry (2016)14: 495-502. IF=3.562

7. Samad Yaseen, Muhammad Khawar Rauf, Sumera Zaib, Amin Badshah, Muhammad Irshad Ali, Muhammad Nawaz Tahir, Jamshed Iqbal. Synthesis, Characterization and Urease Inhibition, in vitro Anticancer and Antileishmanial Studies of Co(III) Complexes with N,N,N′ -Trisubstituted acylthioureas. Inorganica Chimica Acta (2016) 443: 69–77.

IF=2.04

2015

8. Hamid Saeed Shah, Sachin A. Joshi, Ali Haider, Ulrich Kortz, Nisar-ur-Rehman,

Jamshed Iqbal. Synthesis of chitosan-coated polyoxometalate nanoparticles against cancer and its metastasis. RSC Advances (2015) 5: 93234-93242. IF=3.84

9. Silvio Parpart, Andranik Petrosyan, Syed Jawad Ali Shah, Raji Akeem Adewale, Peter Ehlers, Tatevik Grigoryan, Anna F. Mkrtchyan, Zorayr Z. Mardiyan, Ani J. Karapetyan, Avetis H. Tsaturyan, Ashot S. Saghyan, Jamshed Iqbal, Peter Langer. Synthesis of Optically Pure (S)-2-Amino-5-arylpent-4-ynoic acids by Sonogashira Reactions and their Potential Use as Highly Selective Potent Inhibitors of Aldose Reductase. RSC Advances

(2015) 5: 107400-107412. IF=3.84

10. Abdul Hameed, Syeda T Zehra, Syed Jawad Ali Shah, Khalid M Khan, Rima D Alharthy, Norbert Furtmann, Jürgen Bajorath, Muhammad N Tahir, Jamshed Iqbal. Synthesis, Cholinesterases Inhibition, and Molecular Docking Studies of Pyrido [2, 3B] Pyrazine Derivatives. Chemical Biology & Drug Design. (2015) 5(86): 1115-1120. IF=2.485

11. Imtiaz Khan, Syeda Abida Ejaz, Aliya Ibrar, Shafi Ullah Khan, Syed Jawad Ali Shah, Shahid Hameed, Jim Simpson, Joanna Lecka, Jean Sevigny, Jamshed Iqbal. Influence of the diversified structural variations at the imine functionality of 4-bromophenylacetic acid derivedhydrazoneson alkaline phosphatase inhibition: Synthesis, X-ray structure analysis and molecular modelling studies. RSC Advances (2015) 5: 90806-90818.

IF=3.84

12. Aliya Ibrar, Sumera Zaib, Imtiaz Khan, Farukh Jabeen, Jamshed Iqbal, Aamer Saeed. Facile and expedient access to bis-coumarin-iminothiazole hybrids by molecular hybridization approach: synthesis, molecular modelling and assessment of alkaline phosphatase inhibition, anticancer and antileishmanial potential. RSC Advances (2015) 5: 89919-89931. IF=3.84

13. Aamer Saeed, Syeda Abida Ejaz, Asma Khurshid, Sidra Hassan, Mariya al-Rashida, Muhammad Latif, Joanna Lecka, Jean Sévigny, Jamshed Iqbal. Synthesis, characterization and biological evaluation of N-(2,3-dimethyl-5-oxo-1-phenyl-2,5- dihydro-1H-pyrazol-4-yl)benzamides. RSC Advances (2015) 5: 86428-86439. IF=3.84

14. Aamer Saeed, Sumera Zaib, Saba Ashraf, Javeria Iftikhar, Muhammad Muddassar, Kam Y. J. Zhang, Jamshed Iqbal. Synthesis, Cholinesterase Inhibition and Molecular

Modeling Studies of Coumarin Linked Thioureas Derivatives. Bioorganic Chemistry

(2015) 63: 58-63. IF=2.152

15. Huma Aslam Bhatti, Nizam Uddin, Khurshid Ayub, Bibi Saima, Maliha Uroos, Jamshed Iqbal, Shazia Anjum, Mark Edward Light, Abdul Hameed, Khalid Mohammed Khan. Synthesis, characterization of flavone, isoflavone and 2,3dihydrobenzofuran3carboxylate and density functional theory studies 3carboxylate and density functional theory studies. European Journal of Chemistry (2015) 6(3): 305313.

16. Sumera Zaib, Syed Umar Farooq Rizvi, Sana Aslam, Matloob Ahmad, Syed Mobasher Ali Abid, Mariya al-Rashida, Jamshed Iqbal. Quinolinyl-Thienyl Chalcones as Monoamine Oxidase Inhibitors and their In Silico Modeling Studies. Medicinal Chemistry (2015) 11: 580-589. IF=1.363

17. Imtiaz Khan, Syed Jawad Ali Shah, Syeda Abida Ejaz, Aliya Ibrar, Shahid Hameed, Joanna Lecka, Jose Luis Millan, Jean Sévigny, Jamshed Iqbal. Investigation of quinoline-4-carboxylic acid as a highly potent scaffold for the development of alkaline phosphatase inhibitors: Synthesis, SAR analysis and molecular modelling studies. RSC Advances (2015) 5: 64404-64413. IF=3.84

18. Jamshed Iqbal, Mariya -al- Rashida, Ayesha Babar, Abdul Hameed, Muhammad Siraj Khan, Munawar Ali Munawar, Ather Farooq. Cholinesterase Inhibitory Activities of N- Phenylthiazol-2-Amine Derivatives and their Molecular Docking Studies. Medicinal Chemistry (2015) 11: 489-96. IF=1.363

19. Mariya al-Rashida, Jamshed Iqbal. Inhibition of Alkaline Phosphatase: An Emerging

New Drug Target. Mini-Reviews in Medicinal Chemistry (2015) 15: 41-51. IF=2.903

20. Sumera Zaib, Syed Umar Farooq Rizvi, Sana Aslam, Matloob Ahmad, Mariya al- Rashida, Jamshed Iqbal. Monoamine oxidase inhibition & Molecular Modelling studies of Piperidyl-thienyl & 2-Pyrazoline derivatives of Chalcones. Medicinal Chemistry

(2015) 11: 497-505. IF=1.363

21. Mariya al-Rashida, Syeda Abida Ejaz, Sharafat Ali, Aisha Shaukat, Mehwish Hamayoun, Maqsood Ahmed, Jamshed Iqbal. Diarylsulfonamides and their bioisosteres as dual

inhibitors of alkaline phosphatase and carbonic anhydrase. Bioorganic & Medicinal

Chemistry (2015) 23: 2435-44. IF=2.793

22. Maria Milyutina, Anton Ivanov, Syeda Abida Ejaz, Jamshed Iqbal, Alexander Villinger, Victor O Iaroshenko and Peter Langer. Diversity oriented synthesis of 6-Nitro- and 6- Aminoquinolones and their activity as alkaline phosphatase inhibitors. RSC Advances

(2015) 5: 60054–60078. IF=3.84

23. Jamshed Iqbal, Sumera Zaib, Aamer Saeed, Muhammad Muddassar. Biological

Evaluation of Halogenated Thioureas as Cholinesterases Inhibitors against Alzheimer’s

Disease & Molecular Modeling Studies. Letters in Drug Design & Discovery (2015) 12: 488-94. IF=0.77

24. Thang Ngoc Ngo, Syeda Abida Ejaz, Tran Quang Hung, Tuan Thanh Dang, Jamshed Iqbal, Joanna Lecka, Jean Sévigny, Peter Langer. Efficient One-Pot Synthesis of 5- Perfluoroalkylpyrazoles by Cyclization of Hydrazone Dianions. Organic & Biomolecular Chemistry (2015) 13: 8277-90. IF=3.562

25. Abdul Hameed, Khalid Mohammed Khan, Syeda Tazeen Zehra, Ramasa Ahmed, Zahid Shafiq, Syeda Mahwish Bakht, Muhammad Yaqub, Mazhar Hussain, Antonio de la Vega de León, Norbert Furtmann, Jurgen Bajorath, Shad HA, Tahir MN, Jamshed Iqbal. Synthesis, Biological Evaluation and Molecular Docking of N-Phenyl Thiosemicarbazones as Urease Inhibitors. Bioorganic Chemistry (2015) 61: 51-7.

IF=2.152

26. Zafar Iqbal, Shahid Hameed, Sher Ali, Yildiz Tehseen, Mohammad Shahid, Jamshed Iqbal. Synthesis, Characterization, Hypoglycemic and Aldose Reductase Inhibition Activity of Arylsulfonylspiro [Fluorene-9, 5′-Imidazolidine]-2′, 4′-Diones'. European Journal of Medicinal Chemistry (2015) 98: 127-38. IF=3.447

27. Muhammad Khawar Rauf, Samad Yaseen, Amin Badshah, Sumera Zaib, Raffia Arshad, Muhammad Nawaz Tahir, Jamshed Iqbal. Synthesis, Characterization and Urease Inhibition, in Vitro Anticancer and Antileishmanial Studies of Ni (II) Complexes with N, N, N′-Trisubstituted Thioureas. Journal of Biological Inorganic Chemistry (2015) 20: 541-54. IF=2.538

28. Najm Ul Hassan Khan, Sumera Zaib, Kishwar Sultana, Imtiaz Khan, Berline Mougang- Soume, Humaira Nadeem, Mukhtiar Hassan, Jamshed Iqbal. Metal Complexes of Tosyl

Sulfonamides: Design, X-Ray Structure, Biological Activities and Molecular Docking

Studies. RSC Advances (2015) 5: 30125-32. IF=3.84

29. Muhammad Sirajuddin, Saqib Ali, Sumera Zaib, Jamshed Iqbal, Muhammad Nawaz Tahir, Taibi Ben Hadd. Design, structural and spectroscopic elucidation and in vitro antimicrobial, anticancer, antileishmanial, urease inhibition activities and interaction with SS-DNA of newly synthesized amide based carboxylic acid. Inorganica Chimica Acta

(2015) 427: 178–187. IF=2.046

30. Muhammad Ali Hashmi, Hamid Saeed Shah, Afsar Khan, Umar Farooq, Jamshed Iqbal, Viqar Uddin Ahmad, Shagufta Perveen. Anticancer and Alkaline Phosphatase Inhibitory Effects of Compounds Isolated from the Leaves of Olea ferruginea Royle. Records of Natural Products (2015) 9: 164-168. IF=0.868

31. Imtiaz Khan, Syeda Mahwish Bakht, Aliya Ibrar, Saba Abbas, Shahid Hameed, Jonathan

M. White, Usman Ali Rana, Salah Ud-Din Khan, Sumera Zaib, Mohammad Shahid,

Jamshed Iqbal. Exploration of a library of triazolothiadiazole and triazolothiadiazine compounds as a highly potent and selective family of cholinesterase and monoamine oxidase inhibitors: Design, synthesis, X-ray diffraction analysis and molecular docking studies. RSC Advances (2015) 5: 21249–21267. IF=3.84

32. Aamer Saeed, Aqeel Imran, Pervaiz Ali Channar, Mohammad Shahid, Wajahat Mahmood, Jamshed Iqbal. 2-(Hetero (aryl)methylene)hydrazine-1-carbothioamides as potent urease inhibitors. Chemical Biology & Drug Design (2015) 85: 225-230. (2015).

IF=2.485

33. Rabia Raza, Zaiton Ilyas, Sajid Ali, Muhammad Nisar, Muhammad Younas Khokhar,

Jamshed Iqbal. Identification of Highly Potent and Selective α-Glucosidase Inhibitors with Antiglycation Potential, Isolated from Rhododendron arboretum. Records of Natural Products (2015) 9: 262-266. IF=0.868

2014

34. Imtiaz Khan, Aliya Ibrar, Sumera Zaib, Sarfraz Ahmad, Norbert Furtmann, Shahid Hameed, Jim Simpson, Jürgen Bajorath, Jamshed Iqbal. Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: Synthesis, crystal

structure determination, cholinesterase inhibitory activity, and binding mode analysis.

Bioorganic & Medicinal Chemistry (2014) 22: 6163-73. IF=2.793

35. Mariya al-Rashida, Sajjad Sajid, Mehwish Hamayoun, Aisha Iltaf, Jamshed Iqbal. Sulfa Drugs as inhibitors of Carbonic anhydrase: New Targets for the Old Drugs. BioMed Research International (2014) 2014: Article ID 162928, 10 pages. IF=1.579

36.Muhammad Sirajuddin, Saqib Ali, Vickie McKee, Sumera Zaib, Jamshed Iqbal. Organotin (IV) carboxylate derivatives as a new addition to anticancer and antileishmanial agents: Design, physicochemical characterization and interaction with Salmon sperm DNA. RSC Advances (2014) 4: 57505-57521. IF=3.84

37. Aamer Saeed, Yildiz Tehseen, Hummera Rafique, Norbert Furtmann, Jürgen Bajorath, Ulrich Flörke, Jamshed Iqbal. Benzothiazolyl Substituted Iminothiazolidinones and Benzamido-oxothiazolidines as Potent and Partly Selective Aldose Reductase Inhibitors.

Medicinal Chemistry Communications (2014) 5: 1371-1380. IF= 2.495

38. Muhammad Hanif, Muhammad Azhar Hayat Nawaz, Maria V. Babak, Jamshed Iqbal,

Alexander Roller, Bernhard K. Keppler, Christian G. Hartinger. RutheniumII(η6-arene) Complexes of Thiourea Derivatives: Synthesis, Characterization and Urease Inhibition.

Molecules (2014) 19: 8080-92. IF= 2.416

39. Tashfeen Akhtar, Muhammad Ashfaq Khan, Jamshed Iqbal, Peter G. Jones, Shahid Hameed. A facile one pot synthesis of 2-arylamino-5-aryloxylalkyl-1,3,4-oxadiazoles and their urease inhibition studies. Chemical Biology & Drug Design (2014) 84: 92-8.

IF=2.485

40. Zaitoon Ilyas, Hamid Saeed Shah, Rami Al-Oweini, Ulrich Kortz, Jamshed Iqbal

Antidiabetic potentials of polyoxotungstates: in-vitro and in-vivo studies. Metallomics

(2014) 6: 1521-1526. IF=3.585

41.Hamid Saeed Shah, Rami Al-Oweini, Ulrich Kortz, Jamshed Iqbal. Cytotoxicity and Enzyme Inhibition Studies of Polyoxometalates and Their Chitosan Nanoassemblies.

Toxicology Reports (2014) 1: 341-352.

42.Dennis Kleeblatt, Philipp Lebrenz, Martin Hein, Holger Feist, Abdul Matin, Rabia Raza,

Jamshed Iqbal, Qamar Rahman, Alexander Villinger, Peter Langer. Synthesis and Antiproliferative Activity of N-Glycosyl-3,3-diaryloxindoles. RSC Advances (2014) 4: 22828-22839. IF=3.84

43.Aamer Saeed, Mariya al-Rashida, Mehwish Hamayoun, Amara Mumtaz, Jamshed Iqbal. Carbonic anhydrase inhibition by 1-aroyl-3-(4-aminosulfonylphenyl)thioureas. Journal of Enzyme Inhibition and Medicinal Chemistry (2014) 29: 901-905. IF=2.332

44.Sana Aslam, Sumera Zaib, Matloob Ahmad, John M. Gardiner, Aqeel Ahmad, Abdul Hameed, Norbert Furtmann, Michael Gütschow, Jürgen Bajorath, Jamshed Iqbal. Novel structural hybrids of pyrazolobenzothiazines with benzimidazoles as cholinesterase inhibitors. European Journal of Medicinal Chemistry (2014) 78:106-117. IF=3.447

45.Sumera Zaib, Aamer Saeed, Karin Stolte, Ulrich Flörke, Mohammad Shahid, Jamshed Iqbal. New aminobenzenesulfonamide-thiourea conjugates: Synthesis and Carbonic anhydrase inhibition and docking studies. European Journal of Medicinal Chemistry

(2014) 78: 140-150. IF=3.447

46.Imtiaz Khan, Sumera Zaib, Aliya Ibrar, Nasim Hasan Rama, Jim Simpson, Jamshed Iqbal. Synthesis, crystal structure and biological evaluation of some novel 1,2,4- triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines. European Journal of Medicinal Chemistry (2014) 78: 167-177. IF=3.447

47.Denis Prodius, Hamid Saeed Shah, Jamshed Iqbal, Anastasia Macaeva, Anatoli Dimoglo, George E. Kostakis, Nicolas Zill, Fliur Macaev, Annie K. Powell. A novel example of double 6-exo-trig heterocyclization: nitrile conversion to new anticancer active (HeLa cells) primary amine ionic liquids. Chemical Communications (2014) 50: 4888-4890. IF=6.834

48.Aamer Saeed, Pervez A. Mahesar, Sumera Zaib, Muhammad Siraj Khan, Abdul Matin,

Jamshed Iqbal. Synthesis, cytotoxicity and molecular modeling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases. European Journal of Medicinal Chemistry (2014) 78: 43-53. IF=3.447

49.Friedrich Erben, Dirk Michalik, Holger Feist, Dennis Kleeblatt, Martin Hein, Abdul Matin, Jamshed Iqbal, Peter Langer. Synthesis and Antiproliferative Activity of (Z)-1- Glycosyl-3-(5-oxo-2-thioxoimidazolidin-4-ylidene)indolin-2-ones and (Z)-3-(2- Glycosylsulfanyl-4-oxo-4,5-dihydro-thiazol-5-ylidene)indolin-2-ones. RSC Advances

(2014) 4: 10879-10893. IF=3.84

50.Aamer Saeed, Muhammad Siraj Khan, Hummera Rafique, Mohammad Shahid, Jamshed Iqbal. Design, synthesis, molecular docking studies and in vitro screening of ethyl 4-(3-

benzoylthioureido) benzoates as urease inhibitors. Bioorganic Chemistry (2014) 52: 1-7.

IF=2.152

51.Fabian Heisig, Sabrina Gollos, Sven J. Freudenthal, Ali El-Tayeb, Jamshed Iqbal, Christa E. Müller. Synthesis of BODIPY Derivatives Substituted with Various Bioconjugatable Linker Groups: A Construction Kit for Fluorescent Labeling of Receptor Ligands. Journal of Fluorescence (2014) 24: 213-230. IF=1.927

52.Shoaib Iqbal, Nisar ur Rehman, Jamshed Iqbal. A capillary electrophoresis based enzyme assay for kinetics and inhibition studies of carbonic anhydrase. Analytical Biochemistry (2014) 444: 16-21. IF=2.219

53.Afsar Khan, Umar Farooq, Fateh Ullah, Jamshed Iqbal, Ather Farooq Khan, Sumera Zaib, Abdur Rahman Khan, Ali Azarpira. Determination of biological activities and total phenolic contents of flowers of Jasminum humile and roots of Dorema aucheri. Journal of the Chemical Society of Pakistan (2014) 36: 291-295. IF=0.345

54.Mariya al-Rashida, Jamshed Iqbal. Therapeutic potentials of ecto-nucleoside triphosphate diphosphohydrolase, ecto-nucleotide pyrophosphatase/ phosphodiesterase, ecto-5′-nucleotidase and alkaline phosphatase inhibitors. Medicinal Research Reviews

(2014) 34: 703-743. IF=8.431

2013

55.Jamshed Iqbal, Aamer Saeed, Rabia Raza, Abdul Matin, Abdul Hameed, Norbert Furtmann, Joanna Lecka, Jean Sévigny, Jürgen Bajorath. Identification of Sulfonic Acids as Efficient Ecto-5'-Nucleotidase Inhibitors. European Journal of Medicinal Chemistry

(2013) 70: 685-691. IF=3.447

56.Shoaib Iqbal, Nisar ur Rehman, Ulrich Kortz, Jamshed Iqbal. Development of a fast and efficient capillary electrophoresis enzyme assay for characterization and inhibition studies of α-glucosidase inhibitors. Journal of Separation Science (2013) 36: 3623-3628.

IF=2.737

57.Muhammad Khawar Rauf, Ammara Talib, Amin Badshah, Sumera Zaib, Khurram Shoaib, Mohammad Shahid, Ulrich Flörke, Imtiaz-ud-Din, Jamshed Iqbal. Solution- phase microwave assisted parallel synthesis of N,N'-disubstituted thioureas derived from benzoic acid: biological evaluation and molecular docking studies. European Journal of Medicinal Chemistry (2013) 70: 487-496. IF=3.447

58. Mariya al-Rashida, Rabia Raza, Ghulam Abbas, Muhammad Shah, George Kostakis, Joanna Lecka, Jean Sévigny, Muhammad Muddassar, Constantina Papatriantafyllopoulou, Jamshed Iqbal. Identification of Novel Chromone Based Sulfonamides as Highly Potent and Selective Inhibitors of Alkaline Phosphatases.

European Journal of Medicinal Chemistry (2013) 66: 438-449. IF=3.447

59.Friedrich Erben, Dennis Kleeblatt, Marcel Sonneck, Martin Hein, Holger Feist, Thomas Fahrenwaldt, Christine Fischer, Abdul Matin, Jamshed Iqbal, Michael Plötz, Jürgen Eberle, Peter Langer. Synthesis and Antiproliferative Activity of Selenoindirubins and Selenoindirubin-N-glycosides. Organic & Biomolecular Chemistry (2013) 11: 3963-78.

IF=3.562

60.Jamshed Iqbal, Shoaib Iqbal, Christa E. Müller. Advances in immobilized enzyme microbioreactors in capillary electrophoresis. Analyst (2013) 138: 3104-16. IF=4.107

61.Shahzad Ahmed, Muhammad Sharif, Khurram Shoaib, Sebastian Reimann, Jamshed Iqbal, Tamás Patonay, Anke Spannenberg, Peter Langer. Synthesis of 2,6-Diaryl-3- (trifluoromethyl)pyridines by Regioselective Suzuki-Miyaura Reactions of 2,6-Dichloro- 3-(trifluoromethyl)pyridine. Tetrahedron Letters (2013) 54: 1669-1672. IF=2.379

62.Saghir Abbas, Saqib Ali, Muhammad Siraj Khan, Masood Parvez, Jamshed Iqbal. Synthesis, crystal structure, enzyme inhibition, DNA protection and antimicrobial studies of di- and triorganotin(IV) derivatives of 2-thiopheneacetic acid. Journal of Coordination Chemistry (2013) 66: 2765-2774. IF=2.012

63.Dennis Kleeblatt, Baraa Siyo, Martin Hein, Viktor Iaroshenko, Jamshed Iqbal, Alexander Villinger, Peter Langer. Synthesis of N,N’-Diglycosylated Isoindigos. Organic & Biomolecular Chemistry (2013) 11: 886-895. IF=3.562

64.Saghir Abbas, Mukhtiar Hussain, Saqib Ali, Masood Parvez, Ahsan Raza, Ali Haider,

Jamshed Iqbal. Structural, Enzyme Inhibition, Antibacterial and DNA Protection Studies of Organotin (IV) Derivatives of Thiophene-2-Carboxylic Acid. Journal of Organometallic Chemistry (2013) 724: 255-261. IF=2.173

65.Muhammad Sharif, Aneela Maalik, Sebastian Reimann, Jamshed Iqbal, Tamás Patonay, Alexander Villinger, Peter Langer. Synthesis and Photophysical Properties of Tetra- and Pentaalkynyl Fluorobenzenes. Tetrahedron (2013) 69: 174-183. IF=2.641

66.Serge-Mithérand Tengho Toguem, Imran Malik, Munawar Hussain, Jamshed Iqbal, Alexander Villinger, Peter Langer. Synthesis of functionalized benzothiophenes and dibenzothiophenes by twofold Heck and subsequent 6p-electrocyclization reactions of 2,3-dibromothiophenes and 2,3-dibromobenzothiophenes. Tetrahedron (2013) 69: 160- 173. IF=2.641

67.Muhammad Sharif, Aneela Maalik, Sebastian Reimann, Jamshed Iqbal, Alexander Villinger, Peter Langer. Synthesis of Functionalized Fluorinated Terphenyls by Site Selective Suzuki-Miyaura Cross-Coupling Reactions of Dibrominated Fluorbenzenes.

Journal of Fluorine Chemistry (2013) 146: 19-36. IF=1.948

68.Iftikhar Ali, Baraa Siyo, Zahid Hassan, Imran Malik, Ihsan Ullah, Asad Ali, Muhammad Nawaz, Jamshed Iqbal, Alexander Villinger, Peter Langer. Synthesis of trifluoromethyl- substituted di- and terphenyls by site-selective Suzuki-Miyaura reactions of various dihalogenated trifluoromethyl-benzene derivatives. Journal of Fluorine Chemistry (2013) 145: 18-34. IF=1.948

69.Zafar Iqbal, Shahid Hameed, Sher Ali, Jamshed Iqbal, Qamar Abbas, Irfan Zia Qureshi. Dual action spirobicycloimidazolidine-2,4-diones: antidiabetic agents and inhibitors of aldose reductase-an enzyme involved in diabetic complications. Bioorganic & Medicinal Chemistry Letters (2013) 23: 488-91. IF=2.42

70.Jamshed Iqbal, Maria Barsukova-Stuckart, Masooma Ibrahim, Syed Usman Ali, Aftab Ahmed Khan, Ulrich Kortz. Polyoxometalates as potent inhibitors for acetyl and butyrylcholinestrases as potential drugs for the treatment of Alzheimer's disease.

Medicinal Chemistry Research (2013) 22: 1224-1228. IF=1.402

71.Aamer Saeed, Sumera Zaib, Arshid Pervez, Amara Mumtaz, Mohammad Shahid,

Jamshed Iqbal. Synthesis, molecular docking studies, and in vitro screening of sulfanilamide-thiourea hybrids as antimicrobial and urease inhibitors. Medicinal Chemistry Research (2013) 22: 3653-3662. IF=1.402

2012

72.Sher Ali, Aamer Saeed, Naeem Abbas, Mohammad Shahid, Michael Bolte, Jamshed Iqbal. Design, synthesis and molecular modelling of novel methyl[4-oxo-2-(aroylimino)- 3-(substituted phenyl)thiazolidin-5-ylidene]acetates as potent and selective aldose reductase inhibitors. Medicinal Chemistry Communications (2012) 3: 1428-1434.

IF=2.495

73.Muhammad Rizwan Maqsood, Muhammad Hanif, Muhammad Rafiq, Muhammad Saleem, Sumera Zaib, Aftab Ahmed Khan, Mazhar Iqbal, Jamshed Iqbal, Nasim Hasan Rama, Sung-Yum Seo, Ki-Hwan Lee. Some Pyridyl- and Thiophenyl- Substituted 1,2,4- Triazolo[3,4-b]1,3,4-thiadiazole Derivatives as Potent Antibacterial. Bulletin of Korean Chemical Society (2012) 33: 4180-4184. IF=0.797

74.Rabia Raza, Abdul Matin, Sundas Sarwar, Maria Barsukova-Stuckart, Masooma Ibrahim, Ulrich Kortz, Jamshed Iqbal. Polyoxometalates as Potent and Selective Inhibitors of Alkaline Phosphatases with Profound Anticancer and Amoebicidal Activities. Dalton Transactions (2012) 41: 14329-36. IF=4.197

75.Ghazwan Ali Salman, Riffat Un Nisa, Viktor O. Iaroshenko, Jamshed Iqbal, Khurshid Ayub, Peter Langer. Pyrrole versus quinoline formation in the palladium catalyzed reaction of 2-alkynyl-3-bromothiophenes and 2-alkynyl-3-bromofurans with anilines. A combined experimental and computational study. Organic & Biomolecular Chemistry

(2012) 10: 9464-9473. IF=3.562

76.Muhammad Hanif, Khurram Shoaib, Muhammad Saleem, Nasim Hasan Rama, Sumera Zaib, Jamshed Iqbal. Synthesis, Urease Inhibition, Antioxidant, Antibacterial and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives. ISRN Pharmacology

928901, 2012.

77.Jamshed Iqbal, Sumera Zaib, Umar Farooq, Afsar Khan, Irum Bibi, Saba Suleman. Antioxidant, Antimicrobial and free radical scavenging potential of arial parts of Periploca aphylla and Ricinus communis. ISRN Pharmacology 563267, 2012.

78.Ahsan Raza, Aamer Saeed, Aliya Ibrar, Muhammad Muddassar, Aftab Ahmed Khan,

Jamshed Iqbal. Pharmacological evaluation and docking studies of 3-Thiadiazolyl- and Thioxo-1,2,4-triazolylcoumarins derivatives as cholinesterase inhibitors. ISRN Pharmacology (2012) 707932: 2012.

79.Muhammad Aslam, Itrat Anis, Nighat Afzal, Ajaz Hussain, Lubna Iqbal, Jamshed Iqbal, Zaitoon Ilyas, Samina Iqbal, Asif Hanif Chaudhry, Muhammad Niaz. Structure-activity relationship study: synthesis, characterization and biological investigation of schiff bases derived from 2-aminophenol and 4-haloacetophenones. International Journal of Current Pharmaceutical Research (2012) 4: 42-46.

80.Rabia Raza, Aamer Saeed, Mubeen Arif, Shamsul-Mahmood, Muhammad Muddassar, Ahsan Raza, Jamshed Iqbal. Synthesis and Biological Evaluation of 3- thiazolocoumarinyl Schiff Base Derivatives as Cholinesterase Inhibitors. Chemical Biology & Drug Design (2012) 80: 605-615. IF=2.485

81.Imtiaz Khan, Muhammad Hanif, Muhammad Tahir Hussain, Aftab Ahmed Khan, Muhammad Adil M. Aslam, Nasim Hasan Rama, Jamshed Iqbal. Synthesis, acetylcholinesterase and alkaline phosphatase inhibition of some new 1,2,4-2 triazole and 1,3,4-thiadiazole derivatives. Australian Journal of Chemistry (2012) 65: 1413-1419.

IF=1.558

82.Rabia Raza, Aamer Saeed, Joanna Lecka, Jean Sévigny and Jamshed Iqbal. Identification of small Molecule Sulfonic Acids as Ecto-5'-Nucleotidase Inhibitors.

Medicinal Chemistry (2012) 6: 1133-39. IF=1.363

83.Muhammad Hanif, Muhammad Saleem, Muhammad T. Hussain, Nasim H. Rama, Sumera Zaib, Muhammad Adil M. Aslam, Peter G. Jones, Jamshed Iqbal. Synthesis, Urease Inhibition, Antioxidant and Antibacterial Studies of Some 4-Amino-5-aryl-3H- 1,2,4-triazole-3-thiones and their 3,6-Disubstituted 1,2,4-Triazolo[3,4-b]1,3,4-thiadiazole Derivatives. Journal of Brazilian Chemical Society (2012) 23: 854-860. IF=1.129

84.Michael Gütschow, Miriam Schlenk, Jürgen Gäb, Minka Paskaleva, Mohamad Wessam Alnouri, Silvia Scolari, Jamshed Iqbal, Christa E. Müller. Benzothiazinones - a novel class of adenosine receptor antagonists structurally unrelated to xanthine and adenine derivatives. Journal of Medicinal Chemistry (2012) 55: 3331–3341. IF=5.447

2011

85.Jamshed Iqbal. An enzyme immobilized micro-assay in capillary electrophoresis for characterization and inhibition studies of alkaline phosphatases. Analytical Biochemistry

(2011) 414: 226-231. IF=2.219

86.Muhammad Adil S. Aslam, Shams-ul Mahmood, Mohammad Shahid, Aamer Saeed,

Jamshed Iqbal. Synthesis, biological assay in vitro and molecular docking studies of new Schiff base derivatives as potential urease inhibitors. European Journal of Medicinal Chemistry (2011) 46: 5473-5479. IF=3.447

87.Jamshed Iqbal, Christa E. Müller. High-sensitivity capillary electrophoresis method for monitoring purine nucleoside phosphorylase and adenosine deaminase reactions by a

reversed electrode polarity switching mode. Journal of Chromatography A (2011) 1218:

4764-71. IF=4.169

88.Rabia Raza, Tashfeen Akhtar, Shahid Hameed, Joanna Lecka, Jamshed Iqbal, Jean Sévigny. Identification of Potent and Selective Human Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase-3 (hNPP3) Inhibitors. The Open Enzyme Inhibition Journal (2011) 4: 17-22.

2010

89.Younis Baqi, Sang-Yong Lee, Jamshed Iqbal, Peter Ripphausen, Anne Lehr, Anja B. Scheiff, Herbert Zimmermann, Jürgen Bajorath. Christa E. Müller. Development of Potent and Selective Inhibitors of ecto-5’-Nucleotidase Based on an Anthraquinone Scaffold. Journal of Medicinal Chemistry (2010) 53: 2076-86. IF=5.447

90.Jamshed Iqbal, Aileen F. Knowles, Christa E. Müller. Development of a microbioreactor with ecto-nucleoside triphosphate diphosphohydrolase 2 (NTPDase2) immobilized on a polyacrylamide-coated capillary at the outlet. Journal of Chromatography A (2010) 1217: 600-04. IF=4.169

2009

91.Ali El-Tayeb, Jamshed Iqbal, Andrea Behrenswerth, Michael Romio, Marion Schneider, Herbert Zimmermann, Jürgen Schrader, Christa E. Müller. Nucleoside-5'- monophosphates as Prodrugs of Adenosine A(2A) Receptor Agonists Activated by ecto- 5'-Nucleotidase. Journal of Medicinal Chemistry (2009) 52: 7669-77. IF=5.447

92.Younis Baqi, Stefanie Weyler, Jamshed Iqbal, Herbert Zimmermann, Christa E. Müller. Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases)

Purinergic Signalling (2009) 5: 91-106. IF=3.886

2008

93.Jamshed Iqbal, Sébastien A. Lévesque, Jean Sévigny, Christa E. Müller. A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for the monitoring of nucleotide pyrophosphatase/phosphodiesterase reactions. Electrophoresis

(2008) 29: 3685-3693. IF=3.028

94.Andreas Brunschweiger, Jamshed Iqbal, Frank Umbach, Anja B. Scheiff, Mercedes N. Munkonda, Jean Sévigny, Aileen F. Knowles, Christa E Müller. Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide. Journal of Medicinal Chemistry (2008) 51: 4518-4528.

IF=5.447

95.Jamshed Iqbal, David Jirovsky, Sang-Yong Lee, Herbert Zimmermann, Christa E. Müller. Capillary electrophoresis-based nano-scale assays for monitoring ecto-5’- nucleotidase activity and inhibition in preparations of recombinant enzyme and melanoma cell membranes. Analytical Biochemistry (2008) 373: 129-140. IF=2.219

2007

96.Jamshed Iqbal, Leonardo Scapozza, Gerd Folkers, Christa E. Müller. Development and validation of a fast and convenient capillary electrophoresis method for the characterization of herpes simplex virus type 1 (HSV-1) thymidine kinase substrates and inhibitors. Journal of Chromatography B (2007) 846: 281-290. IF=2.729

2006

97.Jamshed Iqbal, Joachim C. Burbiel, Christa E. Müller. Development of off-line and in- line capillary electrophoresis methods for the screening and characterization of adenosine kinase inhibitors and substrates. Electrophoresis (2006) 27: 2505-2517. IF=3.028

98.Daniela C. G. Bertarelli, Martina Diekmann, Alaa M. Hayallah, Dorothee Rüsing,

Jamshed Iqbal, Birgit Preiss, Eugen J. Verspohl, Christa E. Müller. Characterization of human and rodent native and recombinant adenosine A2B receptors by radioligand binding studies. Purinergic Signalling (2006) 2: 559-571. IF=3.886

99.Christa E. Müller, Jamshed Iqbal, Younis Baqi, Herbert Zimmermann, Anita Röllich, Holger Stephan. Polyoxometalates – a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorganic & Medicinal Chemistry Letters

(2006) 16: 5943-5947. IF=2.42

100.Christa E. Müller, Jamshed Iqbal, Younis Baqi. Capillary Electrophoresis Nano- assays Novel in vitro Screening Methods for Future Drugs. Screening - Trends in Drug Discovery (2006) 7: 26–28.

2005

101.Jamshed Iqbal, Petra Vollmayer, Norbert Braun, Herbert Zimmermann, Christa E. Müller. A capillary electrophoresis method for the characterization of ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) and the analysis of inhibitors by in- capillary enzymatic microreaction. Purinergic Signalling (2005) 1: 349-358. IF=3.886

2004

102. Stefan Kehraus, Simone Gorzalka, Christian Hallmen, Jamshed Iqbal, Christa E. Müller, Anthony D. Wright, Michael Wiese, Gabriele M. König. Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative. Journal of Medicinal Chemistry (2004) 47: 2243-2255. IF=5.447

Conferences & Workshops Attended

1. Jamshed Iqbal, 1st International Conference on “Recent innovations in Pharmaceutical Sciences”, March 3- 5, 2015, Riphah International University, Islamabad, Pakistan.

2. Jamshed Iqbal, International Conference on “Exploring New Avenues In Medicinal Chemistry: Opportunities And Challenges” January 21-23, 2015, Forman Christian College (A Chartered University) Lahore, Pakistan.

3. Jamshed Iqbal, 14th Asian Symposium On Medicinal Plants, Spices and other Natural Products (ASOMPS), December 9-12, 2013, H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.

4. Jamshed Iqbal, 11th Shokat Khanam Cancer Symposium, November 9-11, 2012, Lahore, Pakistan.

5. Jamshed Iqbal, International Scientific Spring (ISS) -2012 at National Centre for Physics, Islamabad from March 5-9, 2012 and Workshop on Nano Technology on

March 10, 2012.

6. Jamshed Iqbal, Rabia Raza, Abdul Matin, Sundas Sarwar, Maria Barsukova-Stuckart, Masooma Ibrahim, Ulrich Kortz. Polyoxometalates as potent and selective inhibitors of alkaline phosphatases with profound anticancer and amoebicidal activities. 11th Shokat Khanam Cancer Symposium, November 9-11, 2012, Lahore, Pakistan.

7.Rabia Raza, Jamshed Iqbal, Abdul Matin, Sundas Sarwar, Maria Barsukova-Stuckart, Masooma Ibrahim, Ulrich Kortz, Polyoxotungstates as inhibitors of cancer regulating enzymes. 11th Shokat Khanam Cancer Symposium, November 9-11, 2012, Lahore, Pakistan.

8.Jamshed Iqbal, 9th International and 21st national Chemistry Conference, March 14-16, 2011, University of Karachi, Karachi, Pakistan.

9.Jamshed Iqbal, 9th International and 21th National Chemistry Conference, March 14-16, 2011, Jointly organized by H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences and Department of Chemistry, University of Karachi, Karachi, Pakistan.

10.Rabia Raza and Jamshed Iqbal, Development of enzyme immobilized micro-assay in capillary electrophoresis for characterization and inhibition studies of alkaline phosphatase. 9th International and 21st national Chemistry Conference, March 14-16th, 2011. University of Karachi, Karachi, Pakistan.

11.Miriam Schlenk, Minka Paskaleva, Jamshed Iqbal, Jürgen Gäb, Michael Gütschow, Christa E. Müller. Benzothiazinones – a new class of potent A1-adenosine receptor antagonists. DPhG-Jahrestagung in Braunschweig, 2010 Germany.

12.Jamshed Iqbal and Christa E. Müller. High-sensitivity capillary electrophoresis for monitoring of ecto- purine nucleoside phosphorylase and ecto-adenosine deaminase reactions by large-volume sample stacking. Asia-Pacific International Symposium on Lab on chip. Shanghai, 2009, China.

13.Sabrina Gollos, Fabian Heisig, Sven Jan Freudenthal, Andrea Behrenswerth, Jamshed Iqbal, Ralf Brune, Markus Sauer, Christa E. Müller. New Fluorescent-Labeled adenosine receptor ligands. Purinergic Receptors: New Frontiers for Novel Therapies, Third Joint Italian-German Purine Club Meeting, July 17-20, 2009 Camerino, Italy.

14.Younis Baqi, Stefanie Weyler, Hillmann, Petra, Umbach, Frank, Jamshed Iqbal, Kaulich, Marko, Christa E Müller. Anthraquinones: combinatorial synthesis and structure-activity relationships as non-nucleotide-derived P2Y2 receptor antagonists. Purines 2008 Meeting June 29 – July 2, 2008, Copenhagen, Denmark.

15.Jamshed Iqbal, Younis Baqi, Stefanie Weyler, Herbert Zimmermann, Christa E. Müller. Anthraquinones: structure-activity relationships as inhibitors of ecto-nucleoside

triphosphate diphospho-hydrolases (E-NTPDases). Purines 2008 Meeting June 29 – July

2, 2008, Copenhagen, Denmark.

16.Jamshed Iqbal, Aileen F. Knowles, Christa E. Müller. Ecto-nucleoside triphosphate diphosphohydrolase (NTPDase2) immobilized on a polyacrylamide-coated capillary: on- line monitoring of the enzymatic reaction and screening of inhibitors by capillary. Microscale bioseparations and methods for systems biolog, Berlin, Germany, March 9- 13, 2008.

17.Christa E. Müller, Andreas Brunschweiger, Younis Baqi, Sang-Yong Lee, Jamshed Iqbal, Herbert Zimmermann. Development of Ecto-5’-nucleotidase inhibitors as potential new anti-cancer drugs. XXth International Symposium on Medicinal Chemistry EFMC- ISMC 2008 Vienna, Austria, August 31-September 4, 2008.

18.Andreas Brunschweiger, Jamshed Iqbal, Mercedes N. Munkonda, Sang-Yong Lee, Herbert Zimmermann, Christa E. Müller. Synthesis and characterization of nucleotide mimetics as inhibitors of ecto-5’-nucleotidase and NTPDase1. Deutschen Pharmazeutischen Gesellschaft, Bonn, Germany, October 8-11, 2008.

19.Jamshed Iqbal, Younis Baqi, Stefanie Weyler, Herbert Zimmermann, Christa E. Müller. Anthraquinones: structure-activity relationships as inhibitors of ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases). Deutschen Pharmazeutischen Gesellschaft, Bonn, Germany, October 8-11, 2008.

20.Younis Baqi, Stefanie Weyler, Hillmann Petra, Frank Umbach, Jamshed Iqbal, Kaulich Marko, Christa E. Müller. Anthraquinones: combinatorial synthesis and structure-activity relationships as non-nucleotide-derived P2Y2 receptor antagonists. Deutschen Pharmazeutischen Gesellschaft, Bonn, Germany, October 8-11, 2008.

21.Anne Lehr, Younis Baqi, Herbert Zimmermann, Jamshed Iqbal, Christa E. Müller. Testing of novel Ar (Alk)ylaminoanthraquinone derivatives as inhibitors of Ecto-5’- nucleotidase. Deutschen Pharmazeutischen Gesellschaft, Bonn, Germany, October 8-11, 2008.

22.Sabrina Gollos, Fabian Heisig, Sven J. Freudenthal, Jamshed Iqbal, Ralf Brune, Markus Sauer, Christa E Müller. A Simple route to new, functionalized Bodipy Derivatives. Deutschen Pharmazeutischen Gesellschaft, Bonn, Germany, October 8-11, 2008.

23.Andreas Brunschweiger, Jamshed Iqbal, Mercedes N. Munkonda, Jean Sévigny, Aileen

F.Knowles.; Christa E. Müller. Synthesis and structure-activity relationships of 5'- substituted uridine and adenosine derivatives as Ecto-5'-nucleotidase inhibitors. Second Joint Italian-German Purine Club Meeting, Leipzig, Germany, September 12-15, 2007.

24.Miriam Fast, Jamshed Iqbal, Herbert Zimmermann, Jean Sévigny, Christa E. Müller. Capillary electrophoresis-based nano-scale assays for monitoring ecto-5’-nucleotidase activity and inhibition in preparations of recombinant enzyme and melanoma cell membranes. Second Joint Italian-German Purine Club Meeting Leipzig, Germany,

September 12-15, 2007.

25.Jamshed Iqbal, Jean Sévigny, Christa E. Müller. A novel, highly sensitive capillary electrophoresis method for monitoring ecto-nucleotide pyrophosphatases. Second Joint Italian-German Purine Club Meeting Leipzig, Germany, September 12-15, 2007.

26.Christa E. Müller, Jamshed Iqbal, Younas Baqi. Kapillarelektrophorese-Nano-Assays in der Wirkstofftestung. GIT LABOR-FACHZEITSCHRIFT 2006, 10, 897-900.

27.Jamshed Iqbal, 8th International Symposium on Adenosine and Adenine Nucleotides,

May 24-28, 2006, University of Ferrara, Italy,

28.Christa E. Müller, Jamshed Iqbal, Younas Baqi. Capillary electrophoresis nano-assays Novel in vitro screening methods in the search for future drugs. Screening - Trends in Drug Discovery 2006, 4, 26-28.

29.Jamshed Iqbal, Herbert Zimmermann, Christa E. Müller. Development of a novel, automated method for the characterization and screening of NTPDase inhibitors by in- capillary enzymatic microreaction. Purinergic Signalling 2006, 2, 170-171.

30.Andreas Brunschweiger, Jamshed Iqbal, Mercedes N. Munkonda, Jean Sévigny, Aileen

F.Knowles. Christa E. Müller. Development and structure-activity relationship of ectonucleotidase inhibitors. Purinergic Signalling 2006, 2, 170.

31.Younis Baqi, Jamshed Iqbal, Herbert Zimmermann, Anita Röllich, Holger Stephan, Christa E. Müller. Polyoxometalates – discovery of a new class of ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. 3rd Summer School Medicinal

Chemistry at the University of Regensburg. “Medicinal Chemistry: Molecular

Recognition – Ligand Receptor Interactions”. University of Regensburg, Regensburg, Germany, September 25-27, 2006.

32.Younis Baqi, Jamshed Iqbal, Christa E. Müller. Polyoxometalates - a new class of ecto- nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Graduiertenkolleg 804 Analyse von Zellfunktionen durch kombinatorische Chemie und Biochemie. Bonn- Aachen International Center For Information Technology B-IT. University of Bonn, Bonn, Germany, October 20, 2006.

33.Emmerling, F.; Kraus.; W. Iqbal, J.; Müller, C.E .; Röllich, A.; Stephan, H.; Polyoxotungstates as potent inhibitors for ecto-nucleotidases. 37th International Conference of Coordination Chemistry. Cape Town, South Africa, 13-18th August 2006.

34.Jamshed Iqbal, Christa E. Müller. Development of a novel, capillary electrophoresis based method for the screening of potential adenosine kinase inhibitors. 14th Camerino- Noordwijkerhout Symposium "Ongoing Progress in the Receptor Chemistry" University of Camerino, Camerino, Italy, September 7-11, 2003.

35.Jamshed Iqbal, “Medicinal Chemistry and Pharmacology of Purinergic Receptors”

September 11-13, 2003, University of Camerino, Camerino, Italy.

36.Jamshed Iqbal, 14th Camerino-Noordwijkerhout Symposium "Ongoing Progress in the Receptor Chemistry" September 7-11, 2003, University of Camerino, Camerino, Italy.

37.Jamshed Iqbal, Muhammad Ikram. Determination of lead in road side soil, gasoline by AAS and UV-Vis spectrophotometer and development of micro emulsion method for the determination of lead in gasoline. Quaid-i-Azam University, Islamabad, Pakistan on

October 28-30, 1999.

38.Jamshed Iqbal, 4th DAAD follow-up Seminar (Chemistry) April 29-May 01, 1999,

Quaid-i-Azam University Islamabad, Pakistan.

Workshops & Conferences Organized as a Chief Organizer

1.DAAD-HEC International Summer School “Challenges in Molecular Medicine and Drug Research” (1-3 September, 2014) organized by Centre for Advanced Drug Research, COMSATS, Abbottabad.

2.Three days Workshop on “DNA Sequencing” (10-12 February, 2014) organized by Centre for Advanced Drug Research, COMSATS, Abbottabad.

3.1st International Symposium on “Drug Development- Natural & Synthetic” (25-27 August, 2013) organized by Centre for Advanced Drug Research, COMSATS, Abbottabad.

4.2nd International Symposium on “Drug Development- Natural & Synthetic” (23-25 August, 2015) organized by Centre for Advanced Drug Research, COMSATS, Abbottabad.

Patents

1.Christa E. Müller, Andreas Brunschweiger, Jamshed Iqbal. Preparation of nucleotide mimetics as ectonucleotidase inhibitors. Eur. Pat. Appl. 2007, EP 1860113 A1 20071108.

2.Christa E. Müller, Ali El-Tayeb, Jamshed Iqbal, Jürgen Schrader. Phosphorylated a2a receptor agonists. PCT Int. Appl. 2007, WO 2007107598 A1.

Research projects

1.Higher Education Commission of Pakistan funded project “Development of potent and selective modulators of alkaline phosphatases from natural products as well as synthetic derivatives as lead structures“ amount awarded 10.7 Million for 2015-17.

2.The Organization for the Prohibition of Chemical Weapons (OPCW) of Netherlands funded project “Synthesis and Development of NPPs inhibitors“ for the year 2015-17.

3.“DAAD German-Pakistani Research Collaborations project amount received 5 Million for 2014-15.

4.Higher Education Commission of Pakistan funded project “Provision of Grants to Public

Sector Universities and Degree Awarding Institutions for Maintenance of Scientific

Equipment, HEC” for ‘P/ACE MDQ Capillary Electrophoresis’. amount awarded 0.74

Million for year 2014.

5.“DAAD German-Pakistani Research Collaborations project“ amount received 5 Million for 2013-14.

6.CIIT, Islamabad, “Development of new Antidiabetic Drugs amount received 0.2 Million for 2012.

7.CIIT, Islamabad, “Development of drugs for Alzheimer’s Disease Therapy“ amount received 0.2 Million for 2011.

8.Higher Education Commission of Pakistan funded project “Cloning and Expression of human enzymes in Escherichia Coli, and development of high-throughput capillary electrophoresis and Microchip based nano scale test system for analysis of inhibitors,, amount awarded 7.065 Million, for 2009-10.

9.COMSTECH-TWAS “Design, synthesis and biochemical evaluation of Ecto-5'- Nucleotidase inhibitors as potential anti-tumour agents“ amount received 1.5 Million, for

2010.

Research Collaboration with International/ National Universities

Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Québec (pavillon CHUL), Québec, QC, Canada; and Département de Microbiologie- infectiologie et d’Immunologie, Faculté de Médecine, Université Laval, Québec, QC,

Canada

School of Pharmacy, Building B 2.1., Room 1.13, Saarland State University, D-66041 Saarbruecken, Germany

Institut für Chemie, Abteilung Organische Chemie, Universität Rostock Albert-Einstein-Str. 3a, 18059 Rostock

Department of Life Science Informatics, B-IT, LIMES Program Unit Chemical Biology and Medicinal Chemistry, Rheinische Friedrich-Wilhelms-Universität, Dahlmannstr. 2, D-53113 Bonn, Germany

Zhang Initiative Research Unit, Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

Department of Pharmacy, University of Strathclyde, UK

Dalian Institute of Chemical Pyhsics, CAS, Chinese Academy of Sciences, China.

University of Bonn, Germany.

Fraunhofer Institute for Algorithms and Scientific Computing (SCAI) Sankt Augustin, Germany.

Faculty of Medicine, University of Laval, Canada.

Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology Cambridge, MA, USA.

Quaid-I-Azam University, Islamabad, Pakistan.

HEJ, University of Karachi, Pakistan

FC University, Lahore, Pakistan

Government College University, Faisalabad, Pakistan

Supervision of PhD students

S. No.

Name

Year

Thesis title

1

Mr. Shahzad Ahmed

2009

Synthesis of Novel Derivatives of Fluorinated Pyridines by Palladium Catalyzed SuzukiMiyaura and Sonogashira Coupling Reactions

2

Mr. Khurram Shoaib

2009

Facile, Convenient Synthesis and Physicochemical Characterization of Fluorinated Arenes, Benoxazinones and Benzamides.

3

Ms. Rabia Raza

2009

Development and Validation of Analytical Methods for Screening and Characterization of Enzyme Inhibitors

4

Mr. Hamid Saeed Shah

2012

Synthesis, Characterization and In vitro Evaluation of Anticancer Potential of Chitosan-coated Polyoxometalates Nanoparticles

5

Mr. Mobashir Ali Abid

2013

Synthesis, Biological Investigation and Molecular Docking Studies of Oxygen Heterocyclic Derivatives as Monoamine Oxidase Inhibitors

6

Ms. Syeda Abida Ijaz

2013

Identification and Characterization of Pharmacological Inhibitors of Alkaline Phosphatase Isozymes & Nucleotide Pyrophosphatase Isozymes

7

Mr. Azizullah

2013

Development and Evaluation of Selfassembled Stabilized Supramolecular Hydrogels of Polyoxometalates

8

Mr. Shakeel Shah

2013

Assay Optimization and Identification of New Inhibitors of Acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and Related Enzymes.

9

Ms. Sidra Hassan

2014

Ecto-5’-Nucleotidase as a New Target for Cancer Therapy: In vivo and in vitro study

10

Ms. Muafia Jabeen

2014

Biology-Oriented Synthesis (BIOS) Based Synthesis of Libraries of Novel Deoxy Steroids and their Biological activity

Supervision of M.Phil students

S. No.

Name

Year

Thesis title

1

Mr. Mohammad Siraj Khan

2011

Identification of Novel Serine Protease Inhibitors and Their Implication as a Therapeutic Tool for Various Diseases

2

Ms. Javeria Iftikhar

2012

Assay Development and Characterization of Coumarinyl Oxadiazole and Coumarinyl Thiourea as Cholinesterase Inhibitors

3

Mr. Jawad Ali Shah

2013

Identification of Novel Derivatives as Potent Inhibitors of Cholinesterases, Their Enzyme Kinetics and Molecular Docking Studies

4

Ms. Yildiz Tehseen

2013

Identification and Molecular Modeling Studies of Novel Coumarinyl Thiazoles and Oxadiazole Derivatives as Selective and Potent Inhibitors of Aldehyde Reductase

5

Ms. Syeda Mahwish Bakht

2013

Optimization of Continuous Spectrophotometric Assay for Monoamine Oxidase-B, Selective Inhibition and Molecular Modeling Studies

6

Ms. Naureen Akbar

2014

In Vitro Evaluation of Cytotoxic Potential and Biological Screening of Novel Metal Complexes

7

Ms. Zaib un Nisa

2014

In Vitro and In Silico Screening of Organic compounds against Alkaline Phosphatase and Identification of their Cytotoxic Potential

8

Mr. Shafiullah Khan

2014

In Vitro and In Silico Evaluation of Sulphonamide Derivatives as Dual Inhibitors of Carbonic Anhydrase II and 15- Lipoxygenase